Changes in N-terminal Pro B-type Natriuretic Peptide Concentration: Comparative Study of Percutaneous Transluminal Coronary Angioplasty and Off-Pump Coronary Artery Bypass Graft.
10.3346/jkms.2007.22.1.16
- Author:
Hyun Koo KIM
1
;
Hark Jei KIM
;
Jin Won KIM
;
Young Sang SOHN
;
Young Ho CHOI
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Korea University Medical Center, Seoul, Korea. harkkim@korea.ac.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Reperfusion;
Natriuretic Peptide, Brain;
Angioplasty, Transluminal, Percutaneous Coronary;
Coronary Artery Bypass, Off-Pump
- MeSH:
Peptide Fragments/*blood;
Natriuretic Peptide, Brain/*blood;
Middle Aged;
Male;
Humans;
Female;
*Coronary Artery Bypass, Off-Pump;
*Angioplasty, Transluminal, Percutaneous Coronary;
Aged, 80 and over;
Aged
- From:Journal of Korean Medical Science
2007;22(1):16-19
- CountryRepublic of Korea
- Language:English
-
Abstract:
The goal of this study was to compare the effects of different reperfusion methods on N-terminal B-type natriuretic peptide (NT-proBNP) in percutaneous transluminal coronary angioplasty (PTCA) or off-pump coronary artery bypass (OPCAB) patients. Fifty subjects were enrolled in the study, 32 patients received PTCA and 18 OPCAB. An NT-proBNP measurement was performed before intervention and at 1, 3, and 7 days after the procedures. NT-proBNP levels were not significantly different before intervention (PTCA group 297+/-147.3 vs. OPCAB group 235+/-167.8 pg/mL, p>0.05). However, 1 day after the procedures, NT-proBNP levels were higher in the OPCAB group (PTCA 375+/-256.4 vs. OPCAB 1,415+/-737.6 pg/mL, p<0.05), after 3 days NT-proBNP reached peak levels (PTCA 480+/-363.0 vs. OPCAB 2,119+/-818.4 pg/mL, p<0.05), and levels were reduced after 7 days (PTCA 292+/-243.7 vs. OPCAB 522+/-334.0 pg/mL, p>0.05). PTCA induced a mild and transient increase in NT-proBNP concentration, but OPCAB caused sustained high NT-proBNP levels during the 7 day postoperatively. However, differences between NT-proBNP levels associated with these two modalities showed a tendency to decrease rapidly postoperatively.
