Research progress of lacrimal gland organoids
10.3980/j.issn.1672-5123.2025.3.10
- VernacularTitle:泪腺类器官的研究进展
- Author:
Yaxin MO
1
;
Xinyu LIU
1
;
Huiyi GUO
1
;
Xin CHEN
1
;
Qiang CHEN
1
Author Information
1. Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China
- Publication Type:Journal Article
- Keywords:
organoids;
lacrimal gland;
3D construction technology;
clinical application;
drug development
- From:
International Eye Science
2025;25(3):395-399
- CountryChina
- Language:Chinese
-
Abstract:
The lacrimal gland organoids are innovative in vitro cultured tissue model that mimics the lacrimal gland, retaining its original histological and molecular biological properties. This model can more accurately reproduce the physiological environment of the lacrimal gland, including its ductal system and tear film protein secretion. It offers a new platform for studying the physiopathological basis of the lacrimal gland, establishing disease models, conducting regenerative medicine applications, and performing drug screening. Currently, organoids technology is continuously evolving, with ongoing updates to the methods for in vitro culturing of the lacrimal gland. These advancements gradually address challenges related to cultivation complexity, cost, and time, demonstrating a wide range of application potential. In this paper, we summarize the latest progress in lacrimal gland organoids research both domestically and internationally, exploring the development of lacrimal gland organoids, 3D construction technologies, and their potential for clinical applications, in order to provide new insights for clinical research on lacrimal gland-related diseases and to promote broader application of lacrimal gland organoids in drug development and personalized diagnosis and treatment.
