How far is the functional cure of chronic hepatitis B from complete cure？
- VernacularTitle:慢性乙型肝炎功能性治愈离完全治愈还有多远？
- Author:
Na GAO
1
;
Zhiliang GAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Hepatitis B， Chronic; Functional Cure; Hepatitis B Surface Antigens; DNA， Viral
- From: Journal of Clinical Hepatology 2025;41(1):15-23
- CountryChina
- Language:Chinese
- Abstract: Functional cure is currently the ideal treatment endpoint for chronic hepatitis B （CHB） in China and globally. HBsAg seroclearance and HBV DNA that cannot be detected in peripheral blood for more than 24 weeks marks the regression of hepatitis B virus （HBV） infection. However， there is still a lack of systematic description of the characteristics of intrahepatic HBV markers after HBsAg seroclearance. This article elaborates on the issues including the latest definition of functional cure， the characteristics of intrahepatic virological markers after HBsAg seroclearance， the significance of ultrasensitive serum HBsAg detection， and antiviral therapy for CHB patients with a low level of HBsAg， so as to improve the understanding of functional cure among clinicians.
