Prognostic analysis and establishment of a nomogram of postoperative cervical cancer
10.19405/j.cnki.issn1000-1492.2022.04.023
- Author:
Yifan Feng
1
;
Shuwei Wu
1
;
Yuyang Li
1
;
Min Li
1
Author Information
1. Dept of Obstetrics and Gynecology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- Keywords:
cervical cancer;
prognosis;
nomogram
- From:
Acta Universitatis Medicinalis Anhui
2022;57(4):631-635
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prognostic factors of patients with cervical cancer and establish a nomogram to predict overall survival of patients with cervical cancer.
Methods:The information of age, pathological features, radiotherapy and chemotherapy of 513 patients with cervical cancer were collected. The Log-rank test and Cox regression models were used for analyzing overall survival of patients with cervical cancer. A nomogram was established based on the results of multivariate analysis. The C-index, calibration plots and receiver operating characteristic curves were used to evaluate the predictive ability and accuracy of the nomogram.
Results:A total of 456 patients were followed up in this study, 57 cases were lost to follow-up, the loss rate was 11.11%. As the results of univariate and multivariate analysis showed that the adenocarcinoma, poor differentiation, tumor size ≥4 cm, advanced stage, and no radiotherapy were independent risk factors for overall survival of cervical cancer. A nomogram for overall survival of cervical cancer was established based on multivariate analysis, and after validated, the C-index of the nomogram was 0.83. Meanwhile, the 1-, 3-, 5-year calibration plots of the nomogram matched the 45-degree line well. In addition, the 1-, 3-, 5-year AUC values of the nomogram were 0.836, 0.847 and 0.824, respectively.
Conclusion:Based on the results of multivariate analysis, the five prognostic factors of cervical cancer, including histological type, cell differentiation, tumor size, stage, and radiotherapy were used to establish a nomogram with good predictive ability and accuracy. The establishment of the overall survival nomogram of cervical cancer was useful for gynecological oncologists to make a more accurate assessment of the prognosis of patients with cervical cancer and guide the clinical individualized treatment.
- Full text:2025021815370247555宫颈癌术后预后分析及列线图建立_冯逸凡.pdf
