The Measurement of Disutility of Hypoglycemia on Health-related Quality of Life in Patients with Diabetes:Based on Time Trade-off Survey
	    		
		   		
	    	
    	
    	
   		
        
        	
        		- VernacularTitle:糖尿病患者低血糖事件负效用值测量:基于时间权衡法
 
        	
        	
        	
        		- Author:
	        		
		        		
		        		
			        		Yichi YIN
			        		
			        		
			        		
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			        		;
		        		
		        		
		        		
			        		Zhao SHI
			        		
			        		;
		        		
		        		
		        		
			        		Shunping LI
			        		
			        		
		        		
		        		
		        		
		        		
		        			
			        		
			        		Author Information
			        		
		        		
		        		
			        		
			        		
			        			1. 山东大学齐鲁医学院公共卫生学院卫生管理与政策研究中心·国家卫生健康委员会卫生经济与政策研究重点实验室(山东大学)·山东大学健康偏好研究中心 济南 250012
			        		
		        		
	        		
        		 
        	
        	
        	
        	
        		- Keywords:
        			
	        			
	        				
	        				
			        		
				        		diabetes;
			        		
			        		
			        		
				        		hypoglycemic events;
			        		
			        		
			        		
				        		time trade-off;
			        		
			        		
			        		
				        		disutility
			        		
			        		
	        			
        			
        		
 
        	
            
            
            	- From:
	            		
	            			Chinese Health Economics
	            		
	            		 2024;43(6):64-67
	            	
            	
 
            
            
            	- CountryChina
 
            
            
            	- Language:Chinese
 
            
            
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		        	Abstract:
			       	
			       		
				        
				        	Objective:Evaluating the impact of various hypoglycemic events on the Health-Related Quality of Life(HRQoL)of diabetes patients to provide empirical data for health technology assessment.Methods:The data was collected from a tertiary hospital in Jinan,Shandong Province,China.Health utility was measured using the Time Trade-off(TTO)method,and disutility was calculated based on the formula.Subsequently,the intergroup differences among various hypoglycemic event groups were analyzed.Results:The hypoglycemic events'average utility was all lower than the average utility for diabetics without hypoglycemic events(baseline status).Severe hypoglycemic events(0.108)had higher disutility compared to non-severe hypoglycemic events(0.008).Furthermore,nocturnal severe/non-severe hypoglycemic events(0.118/0.008)exhibited higher average disutility than daytime severe/non-severe hypoglycemic events(0.098/0.007).Conclusion:Optimal diabetes management demands prioritizing the prevention of both severe hypoglycemic events and nocturnal hypoglycemic events.