Research progress on the role of circular RNA in neonatal hypoxic-ischemic encephalopathy
10.12092/j.issn.1009-2501.2024.04.016
- VernacularTitle:环状RNA在新生儿缺氧缺血性脑病中的作用研究进展
- Author:
Yinxia DANG
1
;
Fuhui SHEN
;
Shengxia WANG
;
Xia LU
;
Fan WANG
Author Information
1. 兰州大学第二临床医学院
- Keywords:
neonatal hypoxic ischemic encepha-lopathy;
circRNA;
nerve cell
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(4):466-474
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic-ischemic encephalopathy(HIE)is a major cause of newborn mortality and childhood disability.Despite hypothermia treat-ment being the current standard method,it has its limitations and often produces unsatisfactory out-comes.Additionally,due to time and equipment constraints,hypothermia treatment cannot be promptly administered,leading to high mortality rates or varying levels of neurological impairments even after treatment.Hence,the exploration of al-ternative and effective treatment methods for HIE has become a challenging and highly researched topic in the field of neonatology.Research has shown that HIE induces intricate changes in the neurological system at the physiological,cellular,and molecular levels.Circular RNA(circRNA)exhib-its high expression in the central nervous system and plays a role in regulating physiological and pathophysiological processes.Therefore,circRNA holds promise as a potential therapeutic target for HIE.This article provides a comprehensive over-view of the regulatory effects of circRNA on differ-ent types of neural cells in HIE,aiming to offer new theoretical foundations for the treatment of HIE.
