Mechanism and treatment of mucous hypersecretion in chronic ob-structive pulmonary disease
10.12092/j.issn.1009-2501.2024.04.004
- VernacularTitle:慢性阻塞性肺疾病的黏液高分泌机制及治疗
- Author:
Ting ZHANG
1
;
Rong SUN
;
Yong YANG
;
Weichun LIU
;
Yuping YUAN
;
Xu JU
;
Qian WANG
Author Information
1. 上海市静安区闸北中心医院呼吸与危重症医学科,上海 200070
- Keywords:
chronic mucus hypersecretion;
chron-ic obstructive pulmonary disease;
mechanism;
treat-ment
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(4):383-391
- CountryChina
- Language:Chinese
-
Abstract:
Airway mucus hypersecretion is one of the important pathophysiological and clinical manifestations of chronic obstructive pulmonary disease.It has been reported in the literature that COPD patients with chronic airway mucus hyperse-cretion have more frequent acute exacerbations,more severe lung function decline,and higher hos-pitalizations and mortality.Therefore,it is particu-larly critical to understand the pathogenesis of hy-persecretion of mucus in chronic obstructive pul-monary disease and find out effective treatment.This article focuses on the structure,significance of airway mucus and the mechanism of hypersecre-tion of mucus in chronic obstructive pulmonary dis-ease(COPD).In addition,we also summarized drug and non-drug therapy for chronic airway mucus hy-persecretion in this article.Drug therapy includes traditional drug therapy,some new targeted drug therapy for pathogenesis and traditional Chinese medicine therapy,and non-drug therapy includes smoking cessation,physical therapy and bronchos-copy therapy.We hope that it will provide new ideas and directions for the treatment of mucus hy-persecretion in COPD patients.
