Analysis of Clinical Features and Pregnancy Outcomes of Antenatal and Post-natal HELLP Syndrome
- VernacularTitle:产前和产后HELLP综合征的临床特征以及妊娠结局分析
- Author:
Wei LI
1
;
Liping ZHOU
;
Suya KANG
Author Information
1. 南京医科大学附属苏州医院 苏州市立医院产科,江苏 苏州 215002
- Keywords:
HELLP syndrome;
Preeclampsia;
Pregnancy outcome;
Influencing factors
- From:
Journal of Practical Obstetrics and Gynecology
2024;40(11):905-911
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The clinical characteristics of pregnant women with HELLP syndrome before and after delivery and the risk factors of pregnancy outcomes were analyzed.Methods:A retrospective analysis was con-ducted on 126 cases of HELLP syndrome admitted to The Affiliated Suzhou Hospital of Nanjing Medical University from January 2010 to May 2021,divided into prenatal HELLP group[n=108,98 cases with severe preeclampsia(SPE)]and postpartum HELLP group(n=18,15 cases with SPE),to compare the differences in clinical charac-teristics and pregnancy outcomes between the two groups with the different onset time and whether they were complicated with SPE.Results:①Compared with the postpartum HELLP group,the prenatal HELLP group had higher systolic blood pressure in the third trimester of pregnancy,shorter time from preeclampsia to HELLP syn-drome,higher liver function abnormalities,lower platelet counts,and lower 24-hour urinary protein,with statistically significant differences(P＜0.05).There was no statistically significant differences in adverse pregnancy outcomes and neonatal prognosis between the two groups(P＞0.05).②When combined with SPE,the antenatal HELLP group had a shorter interval from preeclampsia to HELLP syndrome,lower platelet counts,and higher liver en-zymes than the postpartum HELLP group,with statistically significant differences(P＜0.05).③There was no sig-nificant difference in clinical features between the antenatal HELLP group and the postpartum HELLP group when not complicated with SPE(P＞0.05).Conclusions:There is only one difference between prenatal and postnatal HELLP syndrome in terms of the speed of disease progression,the time taken from preeclampsia to HELLP syn-drome,and both can lead to serious maternal and neonatal complications,which should be identified early in clini-cal practice.
