Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress
10.12290/xhyxzz.2023-0452
- VernacularTitle:阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中：机制与研究进展
- Author:
Miaomiao LIU
1
;
Hongmei YUE
2
;
Yating LI
1
;
Jinhui XU
1
;
Xingdong WU
1
;
Haobin ZHU
1
Author Information
1. The First Clinical Medical School, Lanzhou University, Lanzhou 730000, China;
2. The First Clinical Medical School, Lanzhou University, Lanzhou 730000, China;Department of Pulmonary and Critical Care Medicine, the First Hospital of Lanzhou University, Lanzhou 730000, China;
- Publication Type:Review
- Keywords:
obstructive sleep apnea;
intestinal flora;
ischemic stroke;
risk factors;
short-chain fatty acids;
trimethylamine-N-oxide
- From:
Medical Journal of Peking Union Medical College Hospital
2024;15(2):382-386
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke, a cerebrovascular disease with high incidence, high mortality, high disability rate and high recurrence rate, is an important cause of death and disability of middle-aged and elderly people in China, and imposes a huge burden to society and families. Therefore, it is essential to identify the risk factors associated with ischemic stroke and effectively prevent them. Studies have shown that obstructive sleep apnea is an independent risk factor for ischemic stroke. However, the exact pathological mechanism of their association has not been clarified. With the development of next-generation sequencing technology, more and more studies have focused on intestinal microbiota. They have found that obstructive sleep apnea can cause intestinal microbiota changes, and intestinal microbiota may be closely related to ischemic stroke. Therefore, this paper attempts to investigate the relationship between intestinal flora and ischemic stroke, so as to reveal the potential pathological mechanism of ischemic stroke caused by obstructive sleep apnea.
