Development and Translation of Super Long-acting Analgesics
10.12290/xhyxzz.2023-0574
- VernacularTitle:超长效镇痛药物的研发与转化
- Author:
Yumiao HE
1
;
Mohan LI
1
;
Chao MA
2
;
Yuguang HUANG
1
Author Information
1. Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;Joint Laboratory of Anesthesia and Pain, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;
2. Joint Laboratory of Anesthesia and Pain, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China;
- Publication Type:Journal Article
- Keywords:
super long-acting analgesics;
extended-release drug carriers;
translational products
- From:
Medical Journal of Peking Union Medical College Hospital
2024;15(2):251-257
- CountryChina
- Language:Chinese
-
Abstract:
Pain management, listed as the fifth vital sign, has gained increasing attention from clinicians. Conventional analgesics have limited duration, leading to intense monitor and frequent dosing during the early phase in order to prevent the progression of chronic pain. Thus, prolonging the duration of analgesics has become one focus of the pain research. Several strategies, such as adding adjuvants, producing derivatives, and applying extended-release carriers, make it possible for super long-acting analgesics to come into reality. This review briefly introduces the strategies and development of the super long-acting analgesics, including the successful translation and commercialization of the present products of super long-acting analgesics. It also summarizes the application and translation of extended-release drug carriers, providing invaluable reference for the future research on the field of super long-acting analgesics.
