Role of Neutrophil Extracellular Traps in Chronic Obstructive Pulmonary Disease
10.12290/xhyxzz.2023-0396
- VernacularTitle:中性粒细胞胞外陷阱在慢性阻塞性肺疾病中的作用
- Author:
Jinhui XU
1
;
Hongmei YUE
2
;
Miaomiao LIU
1
;
Yating LI
1
;
Xingdong WU
1
;
Haobin ZHU
1
Author Information
1. The First Clinical College of Medicine, Lanzhou University, Lanzhou 730000, China;
2. The First Clinical College of Medicine, Lanzhou University, Lanzhou 730000, China;Department of Respiratory and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, China;
- Publication Type:Review
- Keywords:
chronic obstructive pulmonary disease;
neutrophil extracellular traps;
targeted therapy;
mechanism of action
- From:
Medical Journal of Peking Union Medical College Hospital
2024;15(1):153-159
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease (COPD), a respiratory disease characterized by inflammation due to neutrophil infiltration, has become the third leading cause of death worldwide. After the occurrence of COPD, the persistent accumulation of neutrophils can promote the excessive formation of neutrophil extracellular traps (NETs), which plays an important role in local capture and clearance of pathogens, rapid control of infection, and immune regulation. This article mainly introduces the mechanism of COPD occurrence and NETs formation as well as the research progress of NETs in COPD, and summarizes the relevant drug targets for COPD treatment based on NETs, aiming to provide a reference for further research.
