Study on the Application of Cyclosporine A in Patients with Unexplained Re-peated Implantation Failure
- VernacularTitle:环孢素A在不明原因反复种植失败患者中的应用研究
- Author:
Yixuan WANG
1
;
Jiamei SONG
;
Jia BIE
;
Ya SU
;
Jingsi CHEN
;
Zongyu WANG
;
Yushi MENG
Author Information
1. 昆明医科大学第二附属医院生殖医学科,云南 昆明 650032
- Keywords:
Cyclosporine A;
Unexplained repeated implantation failure;
Clinical pregnancy rate;
Embryo im-plantation rate;
Lymphocyte subsets
- From:
Journal of Practical Obstetrics and Gynecology
2024;40(11):918-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of Cyclosporine A(CsA)in patients with unexplained repeated implantation failure(URIF),and to analyze the changes of peripheral blood lymphocyte subsets after CsA treatment.Methods:105 patients with URIF who underwent frozen-thawed embryo transfer(FET)in the De-partment of Reproductive Medicine in The Second Affiliated Hospital of Kunming Medical University from Septem-ber 30,2021 to March 1,2022 were selected.After informed consent,the patients were divided into CsA group(n=52)and control group(n=53)according to whether they received CsA treatment or not.Pregnancy outcomes and changes in lymphocyte subset were compared between the two groups.Results:The embryo implantation rate and clinical pregnancy rate in CsA group were higher than those in the control group,the difference was statisti-cally significant(48.91%vs.32.56%,P=0.027;53.85%vs.32.08%,P=0.024).The CsA group had a lower ear-ly abortion rate than the control group(10.71%vs.23.53%),but the difference was not statistically significant(P=0.25).The percentage of CD3-CD16+CD56+in CsA group was significantly decreased after treatment[(16.15±5.37)%vs.(18.23±7.10)%,P=0.012],it was also lower than that in the control group[(16.15±5.37)%vs.(18.67±5.16)%,P=0.018].Conclusions:CsA treatment can significantly improve the clinical preg-nancy rate and embryo implantation rate of frozen-thawed embryo transfer in patients with URIF,which may be a-chieved by promoting the distribution of peripheral blood lymphocytes to the direction of embryo implantation,es-pecially by down-regulating the percentage of CD3-CD16+CD56+.CsA has a certain application prospect in the field of assisted reproduction.
