Research progress of phage therapy in orthopedic implant-related infection
10.3760/cma.j.cn112139-20230720-00020
- VernacularTitle:噬菌体治疗在骨科植入物感染中的研究进展
- Author:
Zulipikaer MAIMAITI
1
;
Zhuo LI
;
Chi XU
;
Jun FU
;
Libo HAO
;
Liang LIU
;
Jiying CHEN
;
Wei CHAI
Author Information
1. 首都医科大学附属北京潞河医院骨中心，北京 101199
- Keywords:
Prostheses and implants;
Prosthesis-related infections;
Biofilms;
Bacterial infection;
Bacteriophages;
Antibiotics
- From:
Chinese Journal of Surgery
2024;62(1):81-85
- CountryChina
- Language:Chinese
-
Abstract:
The widespread application of implantable materials has brought about a corresponding increase in implant-related complications, with implant-associated infections being the most critical. Biofilms, which often form on these implants, can significantly impede the effectiveness of traditional antibiotic therapies. Therefore, strategies such as surgical removal of infected implants and prolonged antibiotic treatment have been acknowledged as effective measures to eradicate these infections. However,the challenges of antibiotic resistance and biofilm persistence often result in recurrent or hard-to-control infections, posing severe health threats to patients. Recent studies suggest that phages, a type of virus, can directly eliminate pathogenic bacteria and degrade biofilms. Furthermore, clinical trials have demonstrated promising therapeutic results with the combined use of phages and antibiotics. Consequently, this innovative therapy holds significant potential as an effective solution for managing implant-associated infections. This paper rigorously investigates and evaluates the potential value of phage therapy in addressing orthopedic implant-associated infections, based on a comprehensive review of relevant scientific literature.
