Progress in the potential therapeutic mechanism of mesenchymal stem cell-derived exosomes for liver fibrosis
10.12092/j.issn.1009-2501.2024.04.017
- VernacularTitle:间充质干细胞源性外泌体对肝纤维化潜在治疗机制的研究进展
- Author:
Tingting ZHAO
1
;
Junfeng LI
;
Liting ZHANG
Author Information
1. 兰州大学第一临床医学院
- Keywords:
mesenchymal stem cells;
exosomes;
liver fibrosis;
therapeutics;
mechanism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(4):475-480
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is pathological in most chronic liver diseases.Exosomes secreted by mes-enchymal stem cells(MSCs)can regulate liver fibro-sis through mechanisms such as inhibition of in-flammatory response and proliferation of activated hepatic stellate cells,regulation of immune cells and metabolism.Therefore,MSC-derived exosomes can be used as a cell-free therapy for chronic liver disease,expanding new ideas for the treatment of chronic liver disease.Recent researches on MSC-de-rived exosomes in the treatment of liver fibrosis are reviewed in this article.
