Predictors of curative effect of Quyin Koufuye and its synergistic ef-fect on biologics in the treatment of psoriasis
10.12092/j.issn.1009-2501.2024.04.015
- VernacularTitle:去银合剂疗效的预测因素及其在生物制剂治疗银屑病中的增效作用
- Author:
Juan DU
1
;
Lanmei LIN
;
Canbin DONG
;
Kexiang YAN
;
Jian GAO
Author Information
1. 复旦大学附属华山医院皮肤科,上海 200030
- Keywords:
psoriasis;
biological agents;
recur-rence;
Quyin Koufuye
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(4):460-465
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To assess the efficacy of Quyin Koufuye in different types of psoriasis vulgaris and analyzes the relationship between efficacy and vari-ous disease-related factors,as well as its comple-mentary role in biologic therapy.METHODS:This study included a total of 396 patients with psoria-sis.Based on the patient history,participants were categorized into the biologics group(n=98),Quyin Koufuye-assisted biologics group(n=62),and Quyin Koufuye monotherapy group(n=236).Patient histo-ry data were collected,including gender,duration of illness,disease type,initial site of onset,degree of itching,recurrence status and time,smoking habits,joint pain,family history of psoriasis,nail damage,treatment plan,and PASI/BSA scores.A retrospective analysis was conducted to identify factors influencing the efficacy of Quyin Koufuye and to analyze its combined effects with biologics.RESULTS:Combining Quyin Koufuye with biologics significantly boosted the PASI90 response rate to 72.6％(P=0.014).Responders to PASI50 with Quyin Koufuye experienced longer recurrence intervals(＞6 months)than non-responders(50％vs.33.6％,A=0.045).Influencing factors included psoriasis-affect-ed body surface area(OR=0.960,P=0.000),pro-longed smoking history(OR=2.10,P=0.046),and psoriasis type(OR=2.47,P=0.015).CONCLUSION:This study underscores the synergy of Quyin Kou-fuye and biologics in treating psoriasis,particularly for longer recurrence intervals-factors like smoking history,psoriasis type,and affected body surface area impact Quyin Koufuye's efficacy.
