Clinical Application Analysis of Endometrial Receptivity Test Combined with Personalized Embryo Transfer in Patients with Repeated Implantation Failures
- VernacularTitle:子宫内膜种植窗检测结合个体化胚胎移植对反复种植失败患者的临床应用分析
- Author:
Tingting LI
1
;
Rouzhu CHEN
;
Peigen CHEN
;
Meng YANG
;
Cong FANG
Author Information
1. 中山大学附属第六医院生殖医学中心广东省生育力保存工程技术研究中心,广东广州 510655
- Keywords:
Endometrial receptivity test;
Repeated implantation failure;
Personalized embryo transfer
- From:
Journal of Practical Obstetrics and Gynecology
2024;40(9):729-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of endometrial receptivity test(ERT)combined with per-sonalized embryo transfer in improving pregnancy outcomes in patients with repeated implantation failures.Meth-ods:The clinical data of patients diagnosed with repeated implantation failure at the Reproductive Medicine Cen-ter,The Sixth Affiliated Hospital of Sun Yat-Sen University from March 2019 to August 2022 were retrospectively analyzed,among which 428 patients who underwent endometrial receptivity test were included in the ERT group.396 patients who did not undergo ERT were selected by propensity score matching of SPSS 26.0 software as the control group.We compared the clinical characteristic and pregnancy outcomes of two groups and ana-lyzed the pregnancy outcomes of individualized embryo transfer in patients with normal,delayed by 1 day and de-layed by 2 days of endometrial window of implantation(WOI)after personalized embryo implantation of shifting WOI patients.Results:The clinical pregnancy rate(47.73％vs.12.79％)and the live birth rate(38.97％vs.9.76％)of ERT group were significantly higher than those in the control group(P＜0.05).Moreover,endome-triosis and polycystic ovary syndrome(PCOS)accounted for a higher proportion of infertility factors in the ERT group compared to the control group(P＜0.05).Among 428 patients who underwent ERT,there were 316 pa-tients with normal WOI(73.83％),112 patients with WOI displaced(26.17％).There was no statistical difference in the pregnancy outcome among the three groups of normal WOI delayed by 1 day and WOI delayed by 2 days(P＞0.05).Conclusions:ERT technology combined with personalized embryo transfer protocol can improve the fertility outcomes of RIF patients,especially for those with WOI displacement.ERT technology has application prospect and clinical application value.
