Research progress on dedifferentiated fat cells and their application in oral and maxillofacial bone tissue engi-neering
10.12016/j.issn.2096-1456.2024.03.009
- VernacularTitle:去分化脂肪细胞及其在口腔颌面部骨组织工程中应用的研究进展
- Author:
Yingyi SHEN
1
;
Ximeng CAO
;
Chun XU
Author Information
1. 上海交通大学医学院附属第九人民医院口腔修复科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海(200011)
- Keywords:
regenerative medicine;
tissue engineering;
dedifferentiated fat cells;
cell dedifferentiation;
bone regeneration;
maxillofacial prosthesis;
adipose-derived stem cells;
adipocytes
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;(3):223-228
- CountryChina
- Language:Chinese
-
Abstract:
The identification of suitable seed cells represents a critical scientific problem to be solved in the field of oral and maxillofacial bone tissue regeneration.The application of adipose-derived stem cells(ASCs)in tissue and organ repair and regeneration has been studied extensively.In recent years,dedifferentiated fat(DFAT)cells have also shown broad application prospects in the field of bone tissue engineering.DFAT cells express stem cell-related markers and have the potential to differentiate into adipocytes,osteoblasts,chondrocytes,nerve cells,cardiomyocytes and endothelial cells.In addition,DFAT cells also have the advantages of minimally invasive acquisition,strong proliferation and high homogeneity.Currently,all studies involving the application of DFAT cells in scaffold-based and scaffold-free bone tis-sue engineering can confirm their effectiveness in promoting bone regeneration.However,cytological research still faces some challenges,including relatively low cell culture purity,unclear phenotypic characteristics and undefined dediffer-entiation mechanisms.It is believed that with the continuous development and improvement of isolation,culture,identi-fication and directional induction of osteogenic differentiation methods,DFAT cells are expected to become excellent seed cells in the field of oral and maxillofacial bone tissue engineering in the future.
