Applications of Vaterite in Drug Loading and Controlled Release
10.16476/j.pibb.2024.0303
- VernacularTitle:球霰石在药物装载及控释中的应用
- Author:
Xiao-Hui SONG
1
;
Ming-Yu PAN
1
;
Jian-Feng XU
1
;
Zheng-Yu HUANG
1
;
Qing PAN
1
;
Qing-Ning LI
1
Author Information
1. School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo315211, China
- Publication Type:Journal Article
- Keywords:
vaterite;
drug loading;
controlled release;
drug delivery;
porous nanomaterials
- From:
Progress in Biochemistry and Biophysics
2025;52(1):162-181
- CountryChina
- Language:Chinese
-
Abstract:
Currently, the drug delivery system (DDS) based on nanomaterials has become a hot interdisciplinary research topic. One of the core issues is drug loading and controlled release, in which the key lever is carriers. Vaterite, as an inorganic porous nano-material, is one metastable structure of calcium carbonate, full of micro or nano porous. Recently, vaterite has attracted more and more attention, due to its significant advantages, such as rich resources, easy preparations, low cost, simple loading procedures, good biocompatibility and many other good points. Vaterite, gained from suitable preparation strategies, can not only possess the good drug carrying performance, like high loading capacity and stable loading efficiency, but also improve the drug release ability, showing the better drug delivery effects, such as targeting release, pH sensitive release, photothermal controlled release, magnetic assistant release, optothermal controlled release. At the same time, the vaterite carriers, with good safety itself, can protect proteins, enzymes, or other drugs from degradation or inactivation, help imaging or visualization with loading fluorescent drugs in vitro and in vivo, and play synergistic effects with other therapy approaches, like photodynamic therapy, sonodynamic therapy, and thermochemotherapy. Latterly, some renewed reports in drug loading and controlled release have led to their widespread applications in diverse fields, from cell level to clinical studies. This review introduces the basic characteristics of vaterite and briefly summarizes its research history, followed by synthesis strategies. We subsequently highlight recent developments in drug loading and controlled release, with an emphasis on the advantages, quantity capacity, and comparations. Furthermore, new opportunities for using vaterite in cell level and animal level are detailed. Finally, the possible problems and development trends are discussed.
