Predictive value of serum HCY level on the risk of miscarriage in patients with PCOS undergoing FET
10.19405/j.cnki.issn1000-1492.2022.09.031
- Author:
Zhongshan Lin
1
;
Xiaohua Jiang
1
;
Shujun Yu
1
;
Peipei Guo
1
;
Ping Zhou
1
;
Yunxia Cao
1
;
Zhaolian Wei
1
Author Information
1. Reproductive Medicine Center,Dept of Obstetrics and Gynecology, The First Afiliated Hospital of Anhui Medical University,Hefei 230022; Anhui Province Key Laboratory ofReproductive Health and Genetics ,Hefei 230032; Biopreservation and Artificial Organs ,Anhui Provincial Engineering Research Center,Anhui Medical University,Hefei 230032
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
homocysteine;
pregnancy outcomes;
miscarriage
- From:
Acta Universitatis Medicinalis Anhui
2022;57(9):1503-1507
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To investigate the predictive value of serum homocysteine(HCY) level on the risk of miscarriage in polycystic ovary syndrome(PCOS) patients undergoing frozen-thawed embryo transfer(FET).
Methods:536 PCOS patients and 550 non-PCOS patients with fallopian tube factors(control group) retrospectively were analyzed.The basic characteristics and pregnancy outcomes were compared between the two groups.Also, the basic characteristics between the miscarriage group and the live birth group in PCOS patients were compared.The predictive value of Hcy on the miscarriage of PCOS patients after FET treatment was analyzed.
Results:Compared with the control group, body mass index(BMI),testosterone(T),Hcy, fasting insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR),total cholesterol(TC),number of retrieved oocytes and miscarriage rate increased in PCOS group, while high density lipoprotein-cholesterol(HDL-C),high-quality embryo rate and live birth rate decreased, and the differences were statistically significant(P<0.05).Among PCOS patients, Hcy, FINS and HOMA-IR increased in the miscarriage group compared with live birth group, and the differences were statistically significant(P<0.05).Hcy, FINS and HOMA-IR were independent risk factors for miscarriage in PCOS patients, and the predictive value of Hcy for miscarriage in PCOS patients was greater than FINS and HOMA-IR,and the area under ROC curve(AUC) was 0.829(95%CI=0.755-0.902,P<0.001),the cut-off value was 15.975 μmol/L with a 79.0% sensitivity and a 87.4% specificity, which indicated high predictive value for miscarriage in patients with PCOS.
Conclusion : Serum Hcy level significantly increased in PCOS patients, which has an important predictive value for miscarriage after FET treatment.
- Full text:2024122716404304450血Hcy水平对PCOS患者...ET治疗流产风险的预测价值_林仲珊.pdf
