Optimization Strategy and Practice of Traditional Chinese Medicine Compound and Its Component Compatibility
10.13422/j.cnki.syfjx.20240805
- VernacularTitle:中药复方及组分配伍优化策略与实践
- Author:
Zhihao WANG
1
;
Wenjing ZHOU
1
;
Chenghao FEI
2
;
Yunlu LIU
3
;
Yijing ZHANG
4
;
Yue ZHAO
2
;
Lan WANG
5
;
Liang FENG
6
;
Zhiyong LI
5
Author Information
1. College of Basic Medical Sciences，Shanxi University of Chinese Medicine，Jinzhong 030619，China
2. School of Information Engineering， Minzu University of China，Beijing 100081，China
3. Experimental Research Center， China Academy of Chinese Medical Sciences，Beijing 100700，China
4. School of Pharmacy， Minzu University of China，Beijing 100081，China
5. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
6. College of TCM， China Pharmaceutical University，School of Traditional Chinese Pharmacy，Nanjing 211198，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine （TCM） compounds;
compatibility optimization;
formulation optimization;
multi-objective optimization;
mathematical model
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(1):299-310
- CountryChina
- Language:Chinese
-
Abstract:
Prescription optimization is a crucial aspect in the study of traditional Chinese medicine （TCM） compounds. In recent years， the introduction of mathematical methods， data mining techniques， and artificial neural networks has provided new tools for elucidating the compatibility rules of TCM compounds. The study of TCM compounds involves numerous variables， including the proportions of different herbs， the specific extraction parts of each ingredient， and the interactions among multiple components. These factors together create a complex nonlinear dose-effect relationship. In this context， it is essential to identify methods that suit the characteristics of TCM compounds and can leverage their advantages for effective application in new drug development. This paper provided a comprehensive review of the cutting-edge optimization experimental design methods applied in recent studies of TCM compound compatibilities. The key technical issues， such as the optimization of source material selection， dosage optimization of compatible herbs， and multi-objective optimization indicators， were discussed. Furthermore， the evaluation methods for component effects were summarized during the optimization process， so as to provide scientific and practical foundations for innovative research in TCM and the development of new drugs based on TCM compounds.
