The clinical significance of P300 and EMT⁃related proteins in synovial sarcoma
10.19405/j.cnki.issn1000-1492.2022.02.029
- Author:
Hao Chen
1
;
Zhen Zhang
2
;
Ning Wang
1
;
Shuangshuang Dong
1
;
Xiaojuan Lian
3
;
Weihua Liang
1
;
Jinfang Jiang
1
;
Lijuan Pang
1
;
Yan Qi
4
Author Information
1. Dept of Pathology,Shihezi University School of Medicine & The First Afiliated Hospital to Shihezi University School of Medicine ,Shihezi 832000; National Health Commission Key Laboratory of Prevention and Treatment of Central High Incidence Disease , Shihezi 832000
2. Dept ofPathology, The Third Zhengzhou People ’s Hospital , Zhengzhou 450000
3. Dept of Oncology, Jiangjin District Central Hospital , Chongqing 402260
4. Dept of Pathology,Shihezi University School of Medicine & The First Afiliated Hospital to Shihezi University School of Medicine ,Shihezi 832000; National Health Commission Key Laboratory of Prevention and Treatment of Central High Incidence Disease , Shihezi 832000; Dept ofPathology, Central People ’s Hospital of Zhanjiang , Zhanjiang 524000
- Publication Type:Journal Article
- Keywords:
synovial sarcoma;
P300;
SYT-SSX;
epithelial mesenchymal transition;
immunohistochemistry
- From:
Acta Universitatis Medicinalis Anhui
2022;57(2):315-319, 324
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the role and its clinical significance of P300 in biphasic differentiation and epithelial mesenchymal transition ( EMT) process in synovial sarcoma (SS) by detecting the expression of histone
acetyltransferase P300 and EMT related molecules.
Methods : 40 cases of SS paraffin embedded tissue samples were collected , and the SYT⁃SSX fusion gene subtype was detected by RT⁃PCR. Immunohistochemistry was used to detect the expression of P300 and EMT⁃related molecules.
Results
Conclusion :P300 may be involved in the biphasic differentiation and the EMT process of SS , suggesting that P300 plays a certain role in SS invasion and migration.
- Full text:2024121915211938261滑膜肉瘤中P300与EMT相关蛋白的表达及临床意义_陈浩.pdf
