Study on anti⁃alcoholic fatty liver effect of Gehua Jiejiu Dizhi Decoction based on network pharmacology
10.19405/j.cnki.issn1000-1492.2022.02.018
- Author:
Xueli Wu
1
;
Xiao Feng
2
;
Jie Hao
1
;
Xu Yi
2
Author Information
1. Central Laboratory of The Second Afiliated Hospital of Guizhou University of Traditional Chinese Medicine , Guiyang 550003
2. The Second Clinical Medical College of Guizhou University of Traditional Chinese Medicine , Guiyang 550025
- Publication Type:Journal Article
- Keywords:
Gehua Jiejiu Dizhi Decoction;
alcoholic fatty liver disease;
network pharmacology;
targets;
active compounds
- From:
Acta Universitatis Medicinalis Anhui
2022;57(2):260-2264
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the potential active compounds and effect targets of Gehua Jiejiu Dizhi Decoction
(GJDD) for treatment of alcoholic fatty liver disease(AFLD) based on the network pharmacology.
Methods : The GJDD drug⁃compound data set , compound⁃target data set and AFLD target data set were established , the " TCM⁃compound⁃target" interactive network diagram of GJDD anti⁃AFLD was constructed , and the network was analyzed through Cytoscape to explore GJDD potentially active compounds of anti⁃AFLD and their possible targets.
Results:GJDD might act on PIK3CA , PIK3R1 , MAPK1 , APP and other targets , and achieve its therapeutic purpose through multiple pathways such as inflammation⁃related signaling pathways , hormone⁃related pathways , and apoptosis⁃related signaling pathways.
Conclusion :Through network pharmacology , this study confirms the effectiveness of GJDD in the treatment of AFLD , and provides important guidance for improving the occurrence of AFLD and the research on the intervention mechanism of GJDD.
- Full text:2024121910412374319基于网络药理学方法初探葛花...酒涤脂汤抗酒精性脂肪肝作用_吴雪莉.pdf
