Global and regional cardiac magnetic resonance feature tracking left ventricular strain analysis in assessing early myocardial disease in β thalassemia major patients
10.1186/s44348-024-00026-1
- Author:
Nihal M. BATOUTY
1
;
Ahmad M. TAWFIK
;
Donia M. SOBH
;
Basma N. GADELHAK
;
Shimaa EL‑ASHWAH
;
Mohamed Abdelghafar HUSSEIN
;
Mai GAD
;
A. Ashraf Abd El AZIZ
;
Mahmoud Abd EL‑SHAHED
;
Rasha KARAM
Author Information
1. Department of Diagnostic Radiology, Faculty of Medicine, Mansoura Uni‑ versity, Elgomhoria St., Mansoura 35516, Egypt
- Publication Type:RESEARCH
- From:
Journal of Cardiovascular Imaging
2024;32(1):18-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Cardiac magnetic resonance imaging (CMR) is the modality of choice for quantification of myocardial iron overload in β-thalassemia major patients using the T2* sequence. CMR feature tracking (FT) is a recent magnetic resonance imaging tool that gives an idea about myocardial fibers deformation; thus, it can detect early impairment in myocardial function even before the reduction in ejection fraction.
Methods:This study aims to assess the ability of left ventricular CMR-FT in the early detection of systolic dysfunction in β thalassemia major patients and to correlate it with the degree of myocardial iron overload measured by CMR T2*.This prospective study enrolled 57 β thalassemia major patients who received long-term blood transfusion and 20 healthy controls. CMR was used to evaluate left ventricular volumes, ejection fraction, and the amount of myocardial T2*. A two-dimensional left ventricular FT analysis was performed. Both global and segmental left ventricular strain values were obtained.
Results:The mean global circumferential strain (GCS) and global radial strain (GRS) values were significantly lower in patients compared to control (P = 0.002 and P = 0.006, respectively). No correlation was found between T2* values and ejection fraction; however, there was a significant correlation between T2* values and GCS and GRS (P = 0.012 and P = 0.025, respectively) in thalassemia patients. Regional strain revealed significantly lower values of GCS and GRS in basal regions compared to apical ones (P = 0.000).
Conclusions:Our study revealed that CMR-FT can play a role in the early detection of systolic impairment in thalas‑ semia patients.
