Ablation strategy for idiopathic outflow tract premature ventricular complexes:rationale and design of the ABOUT‑PVC study, a prospective multicenter study
10.1186/s42444-024-00123-8
- Author:
Ji‑Hoon CHOI
1
;
Kyoung‑Min PARK
;
Chang Hee KWON
;
Sung‑Hwan KIM
;
Yoo Ri KIM
;
Jin‑Bae KIM
;
Ki‑Byung NAM
;
Jaemin SHIM
;
Jae‑Sun UHM
;
Hee Tae YU
;
Ki Hong LEE
;
Eue‑Keun CHOI
;
Seongwook HAN
Author Information
1. Division of Cardiology, Department of Internal Medicine, Konkuk Univer‑ sity Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
- Publication Type:RESEARCH
- From:International Journal of Arrhythmia
2024;25(3):16-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:An idiopathic outflow tract premature ventricular complex (OT-PVC) is a common arrhythmia, and the accuracy of site of origin prediction using the 12-lead electrocardiogram (ECG) algorithm is not high. There are no studies about a systematic strategy that can provide practical help to electrophysiologists in OT-PVC mapping and ablation. This study aims to evaluate the efficacy and safety of the proposed ablation protocol and establish an optimal catheter ablation strategy by simultaneously investigating and synthesizing various indicators observed during the mapping procedure.
Methods:and designThis study (ABOUT-PVC) was designed as a prospective multicenter study to enroll 210 patients from 11 tertiary university hospitals over an estimated 27 months. Patients with idiopathic OT-PVC requiring catheter ablation will receive the procedure through a proposed ablation strategy and will be followed up for at least 12 months. The primary outcome is the acute procedural success rate. The secondary outcomes are clinical success rate, procedure time, complication rate, symptom relief, and changes in echocardiographic parameters.
Conclusions:The ABOUT-PVC study was designed to investigate the efficacy and safety of the proposed ablation strategy and establish an optimal catheter ablation strategy. We expect this study to overcome the limitations of the ECG prediction algorithms and provide a practical guide to electrophysiologists, increasing the procedure’s success rate and reducing complications and procedure time.
