Comparison of 3 protocols in the methacholine bronchial provocation test
10.4168/aard.2024.12.3.140
- Author:
Sung-Yoon KANG
1
;
Jiewoo SON
;
Sang Min LEE
;
Sae-Hoon KIM
;
Tae-Bum KIM
;
Sang Pyo LEE
Author Information
1. Division of Pulmonology and Allergy, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Allergy, Asthma & Respiratory Disease
2024;12(3):140-146
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:In Korea, KoKo dosimetry and Aerosol Provocation System (APS) are used in the methacholine provocation test (MBPT). In this study, three protocols of the MBPT were compared.
Methods:In patients showing a positive MBPT using short 2-concentration methods for APS with cumulative provocative doses of methacholine which results in a 20% fall in forced expiratory volume in 1 second (FEV 1) (PD20) ≤ 962.81, the MBPT was repeated, using 14-breaths methods for APS. In them, PD20 of those 2 protocols were compared to each other. Provocative concentration of methacholine which results in a 20% fall in FEV 1 (PC20) in 14-breaths methods was also compared with that of 5-breaths methods in other patients showing a positive MBPT with KoKo dosimettry during the study period.
Results:The positive rate in short 2-concentration methods was 18.1% (43 of 238), while that in 5-breaths methods was 14.0% (6 of 43). They were not different from each other (P= 0.342). In 7 patients who underwent the MBPT twice, using short 2-concentration and subsequent 14-breaths methods. The median of PD20 with a positive MBPT using short 2-concentration methods was 573.8 μg with interquartile range (IQR) of 147.8–682.3 μg, whereas that in repeated MBPT using 14-breaths methods was 526.4 μg (IQR, 95.0– 907.1 μg). They did not differ from each other (P= 0.735). The median of PC20 in MBPT using 14-breaths methods was 4.76 mg/mL (IQR, 0.066–10.3 mg/mL) tended to be higher than that in other 6 patients who showed a positive MBPT using 5-breaths methods, 1.95 mg/mL (IQR, 0.42–4.85 mg/mL), but it was not significant (P = 0.534).
Conclusion:Bronchial hyperresponsiveness was not different in 3 protocols of MBPT.
