Research progress on small-molecule inhibitors of ferroptosis regulatory protein GPX4

VernacularTitle:铁死亡调控蛋白GPX4的小分子抑制剂研究进展
Author: Ruxiong LIU ¹ ; Wanzhen YANG ; Jie TU ; Chunquan SHENG
Author Information

1. 海军军医大学药学系药物化学教研室,上海 200433
Keywords: ferroptosis; GPX4; small molecule inhibitors; glutathione; lipid peroxidation
From: Journal of Pharmaceutical Practice and Service 2024;42(9):375-378
CountryChina
Language:Chinese
Abstract: Ferroptosis,discovered in 2012,is a newly form of non-apoptotic and non-necrotic cell death,which is characterized by an increasement in lipid peroxidation and accumulation of intracellular iron ions.Glutathione peroxidase 4(GPX4)is the fourth member of the selenoprotein GPx family and plays a crucial role in clearing lipid peroxides in cells,making it an important regulator of ferroptosis.Small molecule inhibitors targeting GPX4 can induce ferroptosis,offering a new strategy for treating drug-resistant cancers and neurodegenerative diseases.The protein structure and function of GPX4 were primarily discusseed,and the latest advances in small molecule inhibitors of GPX4 were summarized,which provided a research foundation for developing ferroptosis inducers based on GPX4 inhibition.