Investigate the Role of Intestinal Flora in Cardiovascular Diseases Based on the Intestinal Axis Theory
10.13748/j.cnki.issn1007-7693.20224127
- VernacularTitle:基于肠心轴学说探讨肠道菌群在心血管疾病中的作用
- Author:
Kaiyan YANG
1
;
Huiping WEI
1
;
Ji WANG
1
;
Xu XIN
1
;
Shuling LI
1
;
Jie WANG
1
;
Xinqiang WANG
1
Author Information
1. Cardiovascular Ward I, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
- Publication Type:Other Types
- Keywords:
intestinal axis , intestinal flora , cardiovascular disease , metabolites
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(24):3467-3472
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:The large intestinal flora is interdependent and mutually restricted, and synergistically participates in the physiological metabolism of the body and the digestion of nutrients. The study on intestinal flora and cardiovascular health has become a very important research field. Changes in intestinal flora composition, metabolites and toxins produced by intestinal flora can cause cardiovascular system lesions. Cardiovascular disease(CVD) has become a major health problem due to high morbidity and mortality. The changes in specific intestinal flora have been identified as the key factors in the occurrence and development of CVD. However, the underlying mechanism of how intestinal flora and metabolites produce and affect CVD remains unclear. In this paper, the latest research progress of intestinal flora in regulating CVD through the intestinal cardiac axis are reviewed, focusing on the complex interaction between intestinal microorganisms and their metabolites and the occurrence and development of CVD, as well as the effect of changes in intestinal flora imbalance on the occurrence of cardiovascular events, to discuss a causal link between intestinal flora and the pathogenesis of CVD.
