Molecular virological mechanism of the mother-to-child transmission of hepatitis B virus
- VernacularTitle:HBV母婴传播的分子病毒学机制
- Author:
Yarong SONG
1
;
Jie WANG
;
Jie LI
Author Information
- Keywords: Hepatitis B Virus; Infectious Disease Transmission,Vertical; Genotype
- From: Journal of Clinical Hepatology 2024;40(11):2168-2172
- CountryChina
- Language:Chinese
- Abstract: Chronic hepatitis B virus(HBV)infection is a major global public health threat.In areas with moderate to high prevalence of HBV,mother-to-child transmission(MTCT)remains the main source of chronic HBV infection.With the application of combined immunization of hepatitis B vaccine and hepatitis B immunoglobulin in neonates,there has been a significant reduction in the incidence rate of HBV MTCT,but there is still a high risk of HBV MTCT in infants born to mothers with positive HBeAg and high viral loads.Although antiviral therapy for pregnant women with high HBV viral loads in late pregnancy can further reduce the risk of HBV MTCT,it is still difficult to completely block HBV MTCT.A deep understanding of the molecular virological mechanisms of HBV MTCT can provide clear ideas for blocking HBV MTCT,which is of great significance for the prevention and management of HBV MTCT.
