Research advances of living microorganisms and their derivatives-based strategies for the treatment of bacterial infection
10.16438/j.0513-4870.2023-1060
- VernacularTitle:基于活体微生物及其衍生物的抗细菌感染策略研究进展
- Author:
Xue-yu PU
1
;
Xi WANG
1
;
Gui-quan LIU
1
;
Jian YANG
2
Author Information
1. State Key Laboratory of Component-Based Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2. State Key Laboratory of Component-Based Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
- Publication Type:Research Article
- Keywords:
anti-bacterial infection strategy;
living microorganism;
bacterial derivative;
rug delivery system;
bacterial infection
- From:
Acta Pharmaceutica Sinica
2024;59(5):1186-1195
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the abuse of antibiotics has led to antibiotic tolerance in the process of bacterial treatment, the morbidity and mortality caused by drug-resistant bacterial infection have further increased significantly. Drug delivery systems can be precisely designed to achieve controlled drug release, thereby reducing the risk of antibiotic toxicity and resistance, it is urgent to seek novel drug delivery systems to address the challenges posed by bacterial infections. This review first outlines the epidemic and prevention situation of bacterial infection, and further summarizes living microorganisms and their derivatives-based drug delivery systems, focusing on their natural characteristics such as surface specific proteins, physiological signal sensing, directed movement, and secretion of antibacterial substances, which show great potential in the treatment of bacterial infectious diseases by demonstrating their antibacterial effects. This review aims to provide ideas for the development of novel drug delivery systems based on living microorganisms and their derivatives for the treatment of bacterial infectious diseases.
