Effects of Maternal Biologics Use on Infant Immunization:Recent Research Progress

VernacularTitle:妊娠期使用生物制剂对婴儿疫苗接种影响的研究进展
Author: Yue ZHOU ¹ ; Dandan HU
Author Information

1. 广州医科大学附属妇女儿童医疗中心儿童保健科,广东广州 510623
Keywords: gestation period; infant; vaccination; biological agents; autoimmune diseases
From: Journal of Sun Yat-sen University(Medical Sciences) 2024;45(6):876-882
CountryChina
Language:Chinese
Abstract: Women of childbearing age are at a heightened risk for autoimmune diseases,with an incidence rate ranging from 1.5 to 10 cases per 10000 individuals. Biologic agents,recognized for their efficacy and minimal adverse effects,are commonly utilized in this population. Research indicates significant variability among different biologic agents regardingtheir ability to cross the placental barrier. Currently,the World Health Organization (WHO)and the American Academy of Pediatrics (AAP) have not established a standardized vaccination protocol for infants exposed to these agents during pregnancy. This article aims to review the selection of biologic agents by pregnant women and their effects on fetal development and vaccine immune responses. The goal is to provide clearer guidance for clinical decision-making and to enhance maternal and infant health outcomes.