A new trichothecene macrolide from endophyte Myrothecium roridum associated with Trachelospermum jasminoides
10.16438/j.0513-4870.2024-0415
- VernacularTitle:络石内生菌Myrothecium roridum产生的一个新单端孢霉烯大环内酯
- Author:
Xu HAN
1
;
Xiao-wen LI
2
;
Feng ZHANG
2
;
Lei FANG
2
;
Li SHEN
1
Author Information
1. Medical College of Yangzhou University, Yangzhou 225009, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225009, China
2. Medical College of Yangzhou University, Yangzhou 225009, China
- Publication Type:Research Article
- Keywords:
italic>Trachelospermum jasminoides;
endophyte;
italic>Myrothecium roridum;
secondary metabolite;
trichothecene
- From:
Acta Pharmaceutica Sinica
2024;59(10):2889-2893
- CountryChina
- Language:Chinese
-
Abstract:
Three compounds were obtained from the crude extract of the fermentation broth of endophyte Myrothecium roridum IFB-E008 in Trachelospermum jasminoides by silica gel column chromatography, Sephadex LH-20 gel column chromatography and high performance liquid chromatography. They were determined as 3′-iso-isororidin A (1), verrol (2) and N-acetyltryptamine (3), respectively, through HR-MS, 1D and 2D NMR and literature comparison. 3′-iso-isororidin A (1) is a new trichothecene macrolide that has never been reported in the literature. The in vitro cytotoxicity assay showed that compound 2 had certain cytotoxicity against the human gastric cell line SGC-7901 with half inhibition concentration (IC50) of 59.79 μg·mL-1 (158.1 μmol·L-1), while IC50 value of the positive control cisplatin was 6.58 μg·mL-1 (21.9 μmol·L-1).
