Application of Matching-adjusted Indirect Comparison Methods in Efficacy Evaluation of Traditional Chinese Medicine
10.13288/j.11-2166/r.2024.23.006
- VernacularTitle:匹配调整间接比较法在中医药疗效评价中的应用探讨
- Author:
Guodong LI
1
;
Xinyu HU
2
;
Huijuan CAO
1
Author Information
1. Centre for Evidence-Based Chinese Medicine，Beijing University of Chinese Medicine，Beijing，100029
2. School of Acupuncture-Moxibustion and Tuina，Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
efficacy evaluation of traditional Chinese medicine;
matching adjustment;
indirect comparison;
rando-mized controlled trials
- From:
Journal of Traditional Chinese Medicine
2024;65(23):2413-2418
- CountryChina
- Language:Chinese
-
Abstract:
Randomized controlled trials （RCTs） have been widely used in clinical efficacy evaluation of traditional Chinese medicine （TCM）， but also having limitations such as high cost，time consuming， and difficulty in patient recruitment and enrollment. The introduction of matching adjusted indirect comparison （MAIC） can alleviate the problem caused by the limitation of traditional RCT methodology to some extent. This paper introduced the basic principles of MAIC， and analyzed the similarities and differences， advantages and disadvantages of the two design methods， that is the anchored and the non-anchored. By analyzing two case studies in the evaluation of TCM efficacy， which are acupuncture for paroxysmal migraine and moxibustion for diarrhea-type irritable bowel syndrome， respectively， this paper introduced the methodological characteristics of MAIC in the efficacy evaluation of TCM， explored the strengths and feasibility of MAIC in the evaluation of efficacy evidence in TCM， the evaluation of efficacy of non-pharmacological TCM therapy and the development of new Chinese medicine， and discussed the limitations of existing research， matching factors and sample size. Additionally， the paper offered prospects by combining the simulation treatment comparison method and emulated target trials， with the goal of providing recommendations and references for the clinical efficacy evaluation of TCM.
