Study on the chemical constituents and antitumor activity of ethyl acetate extract of Lindera reflexa from Hunan province
10.16438/j.0513-4870.2023-1279
- VernacularTitle:湖南产山橿乙酸乙酯部位化学成分及抗肿瘤活性研究
- Author:
Shan-shan ZHANG
1
;
Yue HAN
1
;
Ya-di HOU
1
;
Yu-jie WEI
2
;
Xiao-ya SUN
1
;
Sui-qing CHEN
3
Author Information
1. Henan University of Chinese Medicine, Zhengzhou 450046, China; Henan Key Laboratory of Chinese Medicine Resources and Chinese Medicine Chemistry, Zhengzhou 450046, China
2. Henan University of Chinese Medicine, Zhengzhou 450046, China
3. Henan University of Chinese Medicine, Zhengzhou 450046, China; Henan Key Laboratory of Chinese Medicine Resources and Chinese Medicine Chemistry, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
italic>Lindera reflexa;
antitumor activity;
flavonoid;
amide;
lignane
- From:
Acta Pharmaceutica Sinica
2024;59(6):1741-1750
- CountryChina
- Language:Chinese
-
Abstract:
The compounds were isolated and purified by silica gel, MCI, Sephadex LH-20 and semi-preparative high performance liquid chromatography. The structures of the compounds were determined by NMR and MS spectroscopic data. Twenty monomer compounds were isolated from the ethyl acetate extract of Lindera reflexa root from Hunan province, and identified as: (1″S,3″S,6″R)-2′,4′,6′-trihydroxy-3′-[1″-(3″-hydroxy)-p-menthanyl]-chalcone (1), sumadain D (2), quercetin (3), catechin (4), epicatechin (5), N-cis-feruloyltyramine (6), N-trans-feruloyltyramine (7), N-trans-feruloyl-3-methoxytyramine (8), flavifloramides B (9), northalifoline (10), isolariciresinol (11), syringaresinol (12), pinoresinol (13), medioresinol (14), dehydroconiferyl alcohol (15), 4-methoxyl-denudaquinol (16), miliusanal (17), syringic acid (18), abscisic acid (19), (E)-cinnamyl-(E)-cinnamate (20). Compound 1 is a new compound, and compounds 2‒20 have been isolated from Lindera reflexa for the first time. The results showed that compounds 1, 2, 3 and 16 could significantly reduce the survival ability of MGC-803 cells with IC50 values of 5.58, 23.41, 25.72 and 20.96 μmol·L-1, respectively. Compounds 5 and 20 can reduce the survival ability of MGC-803 cells with IC50 values of 98.83 and 89.26 μmol·L-1, respectively.
