Protective effect and mechanism of adiponectin on myocardial inj ury in septic mice
10.19405/j.cnki.issn1000-1492.2022.01.008
- Author:
Luqian Liu
1
;
Ling Chen
2
;
Xuqing Qin
3
;
Wenjun He
1
;
Rui Yang
3
;
Liya Shan
3
;
Xinzhi Li
2
;
Ketao Ma
3
Author Information
1. Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine , Shihezi 832000; Dept of Pathophysiology, Shihezi University School of Medicine , Shihezi 832000
2. Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine , Shihezi 832000
3. Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine , Shihezi 832000; Dept ofPhysiology, Shihezi University School of Medicine , Shihezi 832000
- Publication Type:Journal Article
- Keywords:
apoptosis;
adiponectin;
connexin43;
lipopolysaccharide;
septic myocardial injury
- From:
Acta Universitatis Medicinalis Anhui
2022;57(1):36-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the protective effect of adiponectin APN on myocardial injury caused by sep⁃
sis and its possible mechanism.
Methods
Results :Compared with sham group , the expression of Bax , cleaved Caspase3 protein increased and the expression of Bcl⁃2 protein decreased in LPS group. Compared with LPS group , the injury in APN + LPS group was significantly alleviated , showing that the expression of Bax , cleaved caspase3 protein decreased and the expression of Bcl⁃2 protein increased. Meanwhile , compared with sham group , the expression of Cx43 increased in LPS group and decreased in APN + LPS group.
Conclusion :Adiponectin can attenuate LPS⁃induced cardiac injury in septic mice. The mechanism may be through the inhibition of apoptotic signal pathway and the expression of Cx43.
- Full text:2024112817133348881脂联素对脓毒症小鼠心肌损伤的保护作用及其机制_刘鲁倩.pdf
