Application on the advancements in nanomaterial-based antimicrobial photodynamic therapy in oral infectious diseases
10.12016/j.issn.2096-1456.202330521
- VernacularTitle:基于纳米材料的抗菌光动力治疗在口腔感染性疾病中的应用进展
- Author:
Changxing QU
1
;
Jun LIU
Author Information
1. 口腔疾病防治全国重点实验室国家口腔医学中心 国家口腔疾病临床医学研究中心 四川大学华西口腔医院正畸科,四川 成都(610041)
- Keywords:
antimicrobial photodynamic therapy;
photosensitizer;
reactive oxygenr;
nanomaterials;
chitosan;
graphene oxide;
caries;
periodontitis;
endodontic disease;
oral infectious diseases;
multimodal antimicrobial therapy
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(11):879-885
- CountryChina
- Language:Chinese
-
Abstract:
Antimicrobial photodynamic therapy uses photosensitizers to produce reactive oxygen species under light exposure to inhibit pathogenic bacteria.Although its application in the management of oral infectious diseases has in-creased over recent years,it is limited by inadequate tissue and biofilm penetration and suboptimal bioavailability exhib-ited by individual photosensitizers.These challenges can potentially be surmounted through the integration of nanomate-rials,such as polymers,metals and metal oxides,metal-organic frameworks,and carbon and silicon nanomaterials.Polymers allow the controlled release of photosensitizers through structural adjustments but have low stability,while metals and metal oxides possess strong antibacterial properties but can be potentially toxic.Meanwhile,metal-organic frameworks have flexible structures and multifunctionality but have low stability and potential toxicity.Moreover,carbon and silicon nanomaterials,despite exhibiting excellent antibacterial properties and biocompatibility,have limited appli-cation due to high production costs.Materials with inherent antibacterial properties,such as chitosan and graphene ox-ide,have broader application prospects,as they can form multimodal antibacterial platforms with photosensitizers,en-hancing the antibacterial effects and eliminating infections.Future research could incorporate other functional materials,such as anti-inflammatory agents and immunomodulatory materials,to construct comprehensive therapeutic nanoplat-forms for the treatment of oral infectious diseases.
- Full text:2024112215094066336基于纳米材料的抗菌光动力治疗在口腔感染性疾病中的应用进展.pdf
