Application and development trends of population pharmacokinetic techniques in virtual clinical trials
- VernacularTitle:群体药代动力学技术在虚拟临床试验中的应用与发展趋势
- Author:
Yuming ZHANG
1
,
2
,
3
;
Yixian LIU
1
,
2
;
Li ZHENG
1
,
2
Author Information
1. Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
2. NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
3. West China School of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
- Publication Type:Journal Article
- Keywords:
Population pharmacokinetics;
virtual clinical trials;
modeling and simulation
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2024;31(10):1400-1406
- CountryChina
- Language:Chinese
-
Abstract:
Population pharmacokinetics is a research technique based on computer simulation and data analysis, and it has been employed to investigate the dynamic behavior of drug metabolism in different populations. This approach could address practical challenges such as prolonged clinical trial durations, high costs, and increased difficulty in traditional clinical trials. By comprehensively analyzing differences in the internal drug metabolism processes across populations with varying physiological and pathological conditions, population pharmacokinetics has emerged as an effective method to optimize drug development and clinical applications. This article provides a preliminary overview of the essence of population pharmacokinetics, its application in clinical trials, and potential future trends. We hope to serve as a reference and guidance for the application of new technologies and methods in clinical trials.
