Predictive value of glycemia and serum calcium in aortic root dilation disease: A propensity score matching study
- VernacularTitle:血糖和血钙预测主动脉根部扩张性疾病的倾向性评分匹配研究
- Author:
Ziyao LI
1
;
Zhengkun SONG
2
;
Awut Edris·
1
;
Qiang HUO
3
Author Information
1. Department of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, P. R. China
2. Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China
3. Department of Cardiac Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, P. R. China
- Publication Type:Journal Article
- Keywords:
Aortic root dilation;
aortic dissection;
glycemia;
serum calcium
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2024;31(09):1327-1332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of glycemia and serum calcium on occurrence and development of aortic root dilation disease. Methods The clinical data of patients with aortic root dilation who underwent surgical treatment in the Department of Cardiac Surgery of the First Affiliated Hospital of Xinjiang Medical University from January 2011 to October 2021 were retrospectively collected. They were divided into two groups according to whether they were accompanied by acute aortic dissection (Stanford type A), and were matched with the propensity scoring method. Logistic univariate and multivariate regression analyses were used to analyze the glycemia and the serum calcium of the patients in 24 hours at admission, and their receiver operating characteristic (ROC) curves were plotted. Results Finally 184 pairs of patients were matched, including 297 males with an average age of 48.76±9.62 years and 71 females with an average age of 49.97±10.97 years. There were statistical differences in ethnicity, history of hypertension, aortic root diameter, serum calcium and glycemia between the two groups (P<0.05). Logistic multivariate regression analyses results showed that age＜40 years (OR=4.106, P=0.010), Han nationality (OR=2.863, P<0.001), aortic root diameter＜45 mm (OR=5.063, P<0.001), hypertension (OR=2.736, P=0.001), hyperglycemia (OR=4.426, P<0.001) and hypocalcemia (OR=5.375, P<0.001) were independent risk factors for aortic root dilation disease with dissection. ROC curve analysis suggested that the area under the curve (AUC) of glycemia was 0.742 and the AUC of serum calcium was 0.737, all of which had some predictive value. Conclusion Hyperglycemia and hypocalcemia are risk factors for the development of aortic root dilation disease, and to some extent, they can be used as indicators for screening high-risk patients with aortic root dilation disease.
