The pathogenesis and prevention of dyslipidemia after allogeneic hematopoietic stem cell transplantation
10.3969/j.issn.1674-7445.2024145
- VernacularTitle:异基因造血干细胞移植后血脂异常的发生机制及防治要点
- Author:
Jiayu DONG
1
;
Ying DOU
Author Information
1. 400014 重庆,重庆医科大学附属儿童医院血液肿瘤科国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿童感染与免疫罕见病重庆市重点实验室
- Keywords:
Hematopoietic stem cell transplantation;
Dyslipidemia;
Graft-versus-host disease;
Hematopoiesis reconstruction;
Immunosuppressant;
Infection;
Lipid metabolism;
Statin
- From:
Organ Transplantation
2024;15(6):977-982
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an effective treatment for a variety of hematopoietic and immune system diseases,but it is associated with postoperative complications such as infection and graft-versus-host disease.Dyslipidemia is one of the common complications after allo-HSCT,which is closely related to graft-versus-host disease,the use of immunosuppressants,cardiovascular diseases and metabolic syndrome,etc.Hematopoiesis reconstruction after allo-HSCT is also related to lipid metabolism.Therefore,this article reviews the lipid metabolism after allo-HSCT,the mechanisms and related factors affecting dyslipidemia after allo-HSCT,the impact of dyslipidemia on post-transplant complications,and the prevention and treatment of dyslipidemia after allo-HSCT,aiming to explore the impact and significance of dyslipidemia after allo-HSCT,and to provide references for the prevention and treatment of dyslipidemia after allo-HSCT.
