Development of lung organoid models and their application in health effect assessment of occupational exposure

Yixia LI; Hanqing CHEN; Yi HAN

Return

Development of lung organoid models and their application in health effect assessment of occupational exposure

VernacularTitle:肺类器官模型的发展及其在职业暴露健康效应评估中的应用
Author: Yixia LI ¹ ; Hanqing CHEN ² ; Yi HAN ¹
Author Information

1. Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
2. Department of Nutrition & Food Hygiene, School of Public Health, Capital Medical University, Beijing 100069, China.
Publication Type:Specialcolumn:Newtechniquesandmethodsforstudyofenvironmentalhealtheffects
Keywords: pulmonary organoid; occupational lung disease; three-dimensional bioprinting; organs-on-chips
From: Journal of Environmental and Occupational Medicine 2024;41(10):1103-1108
CountryChina
Language:Chinese
Abstract: The lungs, being the principal respiratory organs in humans, are highly vulnerable to occupational exposure hazards. The rapid industrialization and urbanization in China, coupled with the rise of new industries, have heightened the risk of lung-related occupational hazards for workers, thereby presenting substantial challenges to research in lung-related occupational toxicology. The emerging technology of lung organoids, a three-dimensional cell culture technique, has the potential to replicate human lung structure and function in a laboratory setting, enabling direct observation and assessment of various impacts. Furthermore, the organoid model's short cycles and high throughput play a critical role in the simulation of the occurrence and development of lung impairments and the screening and evaluation of potential therapeutic drugs for occupational lung diseases. As such, the utilization of lung-related organoid technology not only improves the assessment level of the health effects of lung-related occupational exposure, but also enhances researchers' understanding of the pathological mechanisms underlying lung diseases and aids in the development of prevention and treatment strategies, rendering it a valuable tool for investigating occupational lung diseases. This paper provided a comprehensive overview of the advancements in lung organoid models and their biomedical applications, particularly in the evaluation of the potential application in the heath effects of lung-related occupational exposures.