Advances in therapeutic drug monitoring of invasive fungal disease
- VernacularTitle:抗侵袭性真菌病治疗药物监测的研究进展
- Author:
Yuting CHEN
1
;
Zhenghua WU
2
;
Guorong FAN
3
Author Information
1. School of Medicine，Shanghai University，Shanghai 200444，China;Dept. of Clinical Pharmacy，Shanghai General Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200080，China
2. Dept. of Clinical Pharmacy，Shanghai General Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200080，China
3. School of Medicine，Shanghai University，Shanghai 200444，China
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cell transplantation;
hematologic malignancies;
invasive fungal disease;
therapeutic drug
- From:
China Pharmacy
2024;35(20):2565-2570
- CountryChina
- Language:Chinese
-
Abstract:
Invasive fungal disease （IFD） is a deep infectious disease with an overall increasing incidence in patients with hematologic malignancies. Triazoles， polyenes， echinocandins echinocandin antifungal drugs， 5-fluorocytosine and Compound sulfamethoxazole are the main drugs used in the clinical treatment of IFD. Therapeutic drug monitoring for IFD prevention and treatment is helpful to optimize treatment outcomes and reduce adverse effects. In this paper， the effective plasma concentration ranges of the above 5 types of drugs are systematically summarized， and the correlation between the plasma concentration of antifungal drugs and the efficacy and adverse reactions is reviewed. Solid phase extraction combined with ultra-performance chromatography-tandem mass spectrometry is a promising detection method in this research field.
