Effect of melatonin on in vitro fertilization embryo transfer treatment in patients with decreasing ovarian reserve
10.19405/j.cnki.issn1000-1492.2022.01.002
- Author:
Kaijuan Wang
1
;
Qi Zhu
2
;
Ding Ding1
1
;
Chao Zhang
1
;
Yunxia Cao
1
;
Beili Chen
1
;
Zhiguo Zhang
1
Author Information
1. Dept of Obstetrics and Gynecology, The First Afiliated Hospital of Anhui Medical University,Hefei 230022
2. Dept of Biomedical Engineering , Anhui Medical University, Hefei 230032
- Publication Type:Journal Article
- Keywords:
decreasing ovarian reserve;
melatonin;
in vitro fertilization and embryo transfer;
treatment effect
- From:
Acta Universitatis Medicinalis Anhui
2022;57(1):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate whether the application of melatonin (MT) in embryo culture in vitro can improve the treatment effect of in vitro fertilization embryo transfer(IVF⁃ET) in patients with decreasing ovarian reserve (DOR) .
Methods :128 DOR patients receiving assisted reproductive therapy were collected. All patients were treated with an antagonist scheme of super⁃ovulation. Patients were divided into melatonin group (n = 56) and control group (n = 72) according to whether melatonin ( melatonin concentration 10 - 9 mol/L) was added into embryo culture medium.
Results : There was no statistically significant difference in oocytes fertilization rate and cleavage rate between the two groups during later embryo culture , but blastocyst formation rate ( 65. 22% vs 56. 16% ) and high⁃quality blastocyst rate (52. 96% vs 40. 94% ) in the melatonin group were higher than those in the control group , and the differences were statistically significant ( P < 0. 05 ) . There were no significant differences in the implantation rate (50. 00% vs 38. 67% ) and clinical pregnancy rate (48. 39% vs 46. 00% ) of blastocysts after freezing⁃thawing between the two groups , but the cycle number of high⁃quality blastocysts obtained in the melatonin group was higher than that in the control group (85. 71% vs 69. 44% ) , and the difference was statistically significant (P < 0. 05) .
Conclusion :In a way , the application of melatonin in the in vitro culture of early embryos can promote the development of oocytes in patients with DOR , improve the quality of embryos , and finally substantially improve the therapeutic effect of such patients.
- Full text:2024102516425145098褪黑素用于胚胎培养对卵巢储...精-胚胎移植治疗效果的影响_王凯娟.pdf
