Research progress on the regulatory role of NF-κB signaling pathway in ophthalmic diseases
10.3980/j.issn.1672-5123.2024.11.15
- VernacularTitle:NF-κB信号通路在眼科疾病中调控作用的研究进展
- Author:
Xue YAO
1
;
Beibei LIU
1
;
Jie LIU
1
;
Daqing WANG
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China; Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
NF-κB signaling pathway;
ophthalmic diseases;
regulatory role
- From:
International Eye Science
2024;24(11):1769-1773
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor kappa-B(NF-κB), an intricate nuclear transcription factor, is ubiquitously present within the myriad tissues and cells of the human corpus, engaging in a multiplicity of biological processes such as the development of the immune system, immune responses, inflammatory reactions, angiogenesis, and tumorigenesis. Its cardinal role in the pathogenesis of ocular diseases is increasingly illuminated by its prevalence. Owing to the unique architecture of the ocular globe, burgeoning studies have identified the excessive activation or dysregulation of the NF-κB signaling pathway as intimately associated with the progression of a multitude of ocular conditions, including, but not limited to, cataracts, dry eye syndrome, and glaucoma. The modulation of NF-κB activation, by targeting it, offers a potent mechanism for regulating ocular inflammation and mitigating disease progression, holding promise as a potential therapeutic strategy for ophthalmic disorders. An in-depth examination of the NF-κB signaling pathway's role in ocular diseases not only enriches our comprehension of the underlying mechanisms of these ailments, but also lays a crucial foundation for the innovation of new treatment modalities. Therefore, this article endeavors to provide a compendious review of the regulatory effects exerted by the NF-κB signaling pathway in ophthalmic conditions throughout recent years.
