Research progress of melatonin in age-related cataract
10.3980/j.issn.1672-5123.2024.11.08
- VernacularTitle:褪黑素在年龄相关性白内障中的研究进展
- Author:
Jianfeng LI
1
;
Lingqi YANG
1
;
Changqin WANG
1
;
Yang LYU
1
Author Information
1. First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China; Ophthalmology Center; Basic Medical Laboratory;Gansu Key Laboratory of Stem Cell and Gene Medicine, the 940th Hospital of Joint Service Support Forces of the Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
melatonin;
oxidative stress;
inflammation;
autophagy;
aging;
cataract
- From:
International Eye Science
2024;24(11):1733-1737
- CountryChina
- Language:Chinese
-
Abstract:
Aging is a necessary process for organisms.The antioxidant capacity in the body decreases, which induces the activation of inflammasomes, autophagy dysregulation, protein misfolding in the lens, resulting in lens opacification. With the increase of age, the secretion of melatonin and glutathione(GSH)gradually decreased, and the pro-oxidant/pro-inflammatory factors increased, which created ideal conditions for the formation of age-related cataract(ARC). A series of changes such as oxidative stress, inflammation and autophagy dysregulation accompany the occurrence of aging, which is also the basis of various diseases. Melatonin has antioxidant, anti-inflammatory, regulation of autophagy and circadian rhythm effects, and has shown benefits in age-related macular degeneration(ARMD), diabetic retinopathy(DR), and glaucoma. Although phacoemulsification and lens implantation have developed maturely, they consume a lot of medical resources. This article reviews the research of melatonin in ARC, which may prevent/delay the formation of ARC, thereby reducing the economic burden of patients and reducing the loss of medical resources.
