Wnt/β-catenin Signaling Cascades in Cardiovascular Diseases
10.16476/j.pibb.2024.0291
- VernacularTitle:经典Wnt信号通路与心血管疾病
- Author:
Yan-Fei QI
1
;
Yan-Ping LIU
1
;
Wen-Qing XU
1
;
Xiao-Xue YAN
1
Author Information
1. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
- Publication Type:Journal Article
- Keywords:
Wnt/β-catenin pathway;
cardiovascular diseases;
pathological process
- From:
Progress in Biochemistry and Biophysics
2024;51(10):2328-2339
- CountryChina
- Language:English
-
Abstract:
Cardiovascular diseases are a group of disorders of the heart and blood vessels, primarily including coronary heart disease, stroke, and other diseases. It is the world’s leading cause of death, and its incidence is increasing yearly. Hypertension is a major risk factor for cardiovascular disease. Wnt signaling comprises a series of highly conservative cascading events controlling fundamental biological processes. Wnt signaling pathways include the canonical Wnt pathway (or Wnt/β-catenin pathway), the non-canonical planar cell-polarity pathway, and the non-canonical calcium-dependent pathways. Abnormal Wnt signaling promotes cell proliferation and differentiation, cardiac malformations, various malignancies, so drugs targeting Wnt signaling play a great therapeutic potential. Wnt/β‑catenin pathway is involved in the occurrence and development of cardiovascular diseases such as atherosclerosis and stroke by regulating cell proliferation, migration, apoptosis, blood-brain barrier permeability, inflammation, oxidative stress, and immune response. Based on the latest research progress, this review summarizes the role of Wnt/β‑catenin signaling in cardiovascular diseases, in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
