Research progress on the related mechanism of malignant transformation of liver cirrhosis-hepatocellular carcinoma and diagnostic biomarkers
10.3969/j.issn.1006-2483.2024.05.029
- VernacularTitle:肝硬化-肝癌恶性转化的相关机制及诊断生物标志物研究进展
- Author:
Min ZHONG
1
;
Xiaoli YANG
1
Author Information
1. Department of Gastroenterology and Hepatology , West China Hospital, Sichuan Universit y, Chengdu , Sichuan 610041, China
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Liver cirrhosis;
Malignant transformation;
Biomarker;
Diagnosis
- From:
Journal of Public Health and Preventive Medicine
2024;35(5):121-124
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the common malignancies in China, which has the characteristics of insidious onset, strong invasiveness, high recurrence rate and poor prognosis. Its incidence is increasing year by year, and it has become the fifth malignancy that seriously threatens human health. The clinical symptoms of HCC are not typical, which makes it difficult to screen through conventional examinations. Patients are mostly in the advanced stage of HCC when they visit the hospital due to discomfort, bringing adverse effects on the treatment and prognosis of HCC. The malignant transformation of liver cirrhosis-HCC is a transitional stage from benign lesions to malignant lesions, involving proliferative lesions of tumor cells. If the cause is clear and removed in time or appropriate treatment is carried out, it is possible to stop this malignant transformation and prevent the occurrence of HCC. Currently, there is a lack of specific indicators for diagnosing precancerous lesions of HCC, and it is urgent to find more reliable diagnostic methods. Herein, the research results of the pathogenesis and diagnostic biomarkers of HCC in recent years at home and abroad were summarized through concluding related mechanisms of malignant transformation of liver cirrhosis-HCC and potential biomarkers for early diagnosis, aiming to provide a more intuitive theoretical basis for the diagnosis and treatment of HCC in clinical practice.
