Reference Intervals for Research Parameters of Reticulocyte Hemoglobin and Platelet Clumps in Healthy Korean Adults
10.15263/jlmqa.2024.46.1.38
- Author:
Miyoung KIM
1
;
Miyoung KIM
;
Sangkyoon HONG
;
Sangkyoon HONG
;
Nan Young KIM
;
Nan Young KIM
;
Kibum JEON
;
Kibum JEON
;
Jiwon LEE
;
Jiwon LEE
;
Han-Sung KIM
;
Han-Sung KIM
;
Hee Jung KANG
;
Hee Jung KANG
;
Young Kyung LEE
Author Information
1. Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Journal of Laboratory Medicine and Quality Assurance
2024;46(1):38-42
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Automated hematology analyzers report various research parameters. Certain parameters may have clinical implications, whereas others are used to set flags in automated hematology analyzers. In this study, we established sex-specific reference intervals for one reticulocyte parameter and two platelet clump parameters in Korean adults and examined the necessity of separate reference intervals for each sex.
Methods:A total of 264 healthy adults (157 men and 107 women) aged between 18 and 65 years who underwent regular health check-ups were enrolled. Complete blood cell count was measured using Advia2120i (Siemens, Germany) within 4 hours of phlebotomy. Reference intervals were established according to the Clinical and Laboratory Standards Institute EP28-A3 guideline, and the necessity of separate sex-specific reference intervals was examined according to the method outlined by Harris and Boyd.
Results:The reference intervals for each parameter were as follows:reticulocyte hemoglobin (g/L), 132.8–172.0 (men), 96.7–162.8 (women); the number of platelet clumps (# platelet clumps), 10.8–61.0 (men), －22.5–64.4 (women); and %platelet clumps, 0.20–1.49 (men), －0.57–1.53 (women).Reticulocyte hemoglobin showed a significant difference between men and women, whereas # platelet clumps and %platelet clumps did not; however, all three parameters needed separate sex-specific reference intervals.
Conclusions:We established sex-specific reference intervals for a reticulocyte parameter and platelet clumps parameters in Korean adults for the first time.The results could provide helpful information in clinical decision-making and instrument setting.
