Advances in nanodrug delivery systems for posterior segment eye diseases
10.3980/j.issn.1672-5123.2024.10.09
- VernacularTitle:纳米药物递送系统在眼后段疾病中的研究进展
- Author:
Jing XIE
1
;
Su ZHAO
1
;
Zhengjing WANG
1
;
Li PU
1
;
Wei ZHAO
1
Author Information
1. Guizhou Medical University, Guiyang 550004, Guizhou Province, China; Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, China; Guiyang Aier Eye Hospital, Guiyang 550005, Guizhou Province, China
- Publication Type:Journal Article
- Keywords:
nanotechnology;
ocular drug delivery system;
posterior segment disease;
ocular barrier
- From:
International Eye Science
2024;24(10):1569-1575
- CountryChina
- Language:Chinese
-
Abstract:
The complex barriers to drug delivery in the eye make it difficult for traditional ophthalmic preparations to reach pathological tissues in the posterior segment of the eye via ocular surface. Therefore, intravitreal drug injection has been widely used for treating posterior segment diseases, but this invasive approach to drug delivery has disadvantages such as short drug half-lives, repeated injections, and many complications. Ophthalmic nanodrug delivery systems, which can overcome ocular drug delivery barriers, enhance drug permeability, and improve drug bioavailability, now make it possible to efficiently deliver drugs to the posterior segment of the eye. However, the carrier materials utilized for nanomedicine delivery are inherently intricate, and substantial disparities exist among research findings, posing a hindrance to the subsequent advancement of pertinent drug formulations. Consequently, this review centers on the principal physiological obstacles encountered in ocular drug delivery, emphasizing the utilization of diverse nanomedicine delivery systems in posterior segment pathologies. It aims to delve into their research progress in posterior segment diseases and establish a safer, more effective therapeutic approach for treating these ocular conditions.
