Correlation of uric acid to HDL-C ratio with recurrence after radiofrequency ablation of atrial fibrillation
10.19405/j.cnki.issn1000-1492.2024.07.025
- VernacularTitle:尿酸/高密度脂蛋白胆固醇比值与房颤射频消融术后复发的相关性
- Author:
Baolong WANG
1
;
Changhui WANG
Author Information
1. 安徽医科大学第一附属医院心血管内科,合肥 230022
- Keywords:
uric acid;
high-density lipoprotein cholesterol;
atrial fibrillation;
radiofrequency ablation;
late recur-rence
- From:
Acta Universitatis Medicinalis Anhui
2024;59(7):1269-1274
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between uric acid to high-density lipoprotein cholesterol ratio(UHR)and late recurrence after radiofrequency ablation in patients with non-valvular atrial fibrillation(AF).Methods The clinical data of 586 patients with non-valvular AF underwent catheter radiofrequency ablation for the first time from January 2018 to January 2022 were selected,and the study population was classified into a low-value group(n=196),a medium-value group(n=195),and a high-value group(n=195)according to the trichoto-mous method based on the UHR value,with late recurrence of AF as the endpoint event of the follow up.The gener-al data and laboratory indexes were compared among the three groups.Survival curves were estimated and plotted u-sing the Kaplan-Meier method.Multivariate COX regression analysis was used to evaluate the independent correla-tion between UHR and recurrence of AF after ablation,followed by subgroup analysis.Results Late recurrence of AF was documented in a total of 182(31.1％)patients during the follow-up time.The Kaplan-Meier survival curve showed a gradual decrease in the maintenance rate of sinus rhythm across the UHR low-value group,middle-value group,and high-value group(Log-rank test,P＜0.001).In the fully-adjusted model,compared with the patients in the low-value group,the medium-value and high-value groups had a post-ablation late recurrence of AF with HR(95％CI,P)were 1.56(0.99-2.42,P=0.057)and 2.03(1.28-3.23,P=0.003),respectively.Subgroup a-nalysis showed that the association between UHR and late recurrence of AF after ablation was remarkable among pa-tients with aged≥60 years,BMI≥25 kg/m2,persistent AF,LAD≥4.3 cm,hypertension,without heart failure and without hyperlipidemia.Conclusion Higher UHR values in patients with non-valvular AF are independently asso-ciated with an increased risk of late recurrence of AF after radiofrequency ablation procedures.
- Full text:2024091411023627641尿酸_高密度脂蛋白胆固醇比...颤射频消融术后复发的相关性_王保龙.pdf
