Advance in Treatment of Gastroesophageal Reflux Disease with Traditional Chinese Medicine by Regulating Inflammation
10.13422/j.cnki.syfjx.20240813
- VernacularTitle:中药调节炎症反应治疗胃食管反流病的研究进展
- Author:
Zhengyan JIANG
1
;
Zhiguang SUN
2
;
Liang ZHENG
1
;
Wei WEN
1
Author Information
1. Jiangsu Province Second Hospital of Traditional Chinese Medicine， Nanjing 210000，China
2. Nanjing University of Chinese Medicine， Nanjing 210029，China
- Publication Type:Journal Article
- Keywords:
gastroesophageal reflux disease （GERD）;
Chinese medicine prescription;
Chinese herbal medicine;
inflammation;
intestinal flora
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(20):264-273
- CountryChina
- Language:Chinese
-
Abstract:
Gastroesophageal reflux disease （GERD） is a prevalent chronic digestive disorder， affecting about 20% of the population. In addition to the typical symptoms of acid regurgitation and pyrosis， GERD can lead to chronic esophageal mucosal inflammation， thereby increasing the risk of esophageal carcinoma. Proton pump inhibitors （PPIs） have emerged as the primary pharmacological intervention due to their efficacy in reducing gastric acid production. However， the long-term use of PPIs is associated with various complications， including malabsorption of nutrients， heightened susceptibility to enteric infections， and an elevated risk of fractures. These concerns have driven the pursuit of safer and more efficacious therapeutic alternatives by both patients and healthcare providers. Recent studies have highlighted the role of persistent inflammation triggered by irritation of the esophageal epithelial cells in the pathogenesis of GERD. Such inflammation not only exacerbates mucosal damage but also contributes to the chronicity and complexity of the disease. Consequently， the development of novel anti-inflammatory therapeutic strategies has become a focus in contemporary research. Chinese herbal medicine prescriptions， with distinctive anti-inflammatory and antioxidant properties， offer a promising avenue for the management of GERD. These prescriptions， composed of a variety of herbal medicines， are prescribed in accordance with the traditional Chinese medicine （TCM） principle of harmonizing Qi， blood， and Yin-Yang， thereby addressing the underlying disease processes. Among the numerous Chinese herbal medicine prescriptions for GERD， ingredients such as Coptidis Rhizoma， Bupleuri Radix， Euodiae Fructus， Glycyrrhizae Radix et Rhizoma， and Atractylodis Macrocephalae Rhizoma are commonly utilized for their effects of inhibiting inflammation， modulating immune functions， and alleviating oxidative stress. Despite the potential in treating GERD， concrete evidence-based medical proof of these prescriptions remains limited. This review summarizes the anti-inflammatory mechanisms and prospects of Chinese herbal medicines in treating GERD， providing an outlook on the value of these medicines in the anti-inflammatory management of GERD.
