A minireview on lipid metabolism and lipid-associated nutritional interventions in childhood cancers

Yanran SHEN; Xinyu BI; Yangyi GONG; Enming SONG; Ling TAO

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A minireview on lipid metabolism and lipid-associated nutritional interventions in childhood cancers

VernacularTitle:脂质代谢和脂类营养干预在儿童癌症中的研究进展
Author: Yanran SHEN ¹ ; Xinyu BI ¹ ; Yangyi GONG ² ; Enming SONG ³ ; Ling TAO ⁴
Author Information

1. School of Public Health/Institute of Nutrition, Fudan University, Shanghai 200032, China.
2. Institute of Optoelectronics/Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200433, China.
3. Institute of Optoelectronics/Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai 200433, China;State Key Laboratory of Medical Neurobiology/MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.
4. School of Public Health/Institute of Nutrition, Fudan University, Shanghai 200032, China;State Key Laboratory of Medical Neurobiology/MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.
Publication Type:Review
Keywords: lipid metabolism; pediatric cancer; nutritional intervention
From: Journal of Environmental and Occupational Medicine 2024;41(8):934-940
CountryChina
Language:Chinese
Abstract: Cancer is a leading cause of mortality in children and results in a significant disease burden. Lipid metabolic reprogramming emerges as a pivotal cancer hallmark, bearing profound implications for understanding tumorigenesis, developing treatment strategies, and improving prognoses. However, research on lipid metabolism and lipid nutritional interventions related to childhood cancers is notably limited compared to adult cancers. This review focused on the current understanding of fatty acid, cholesterol, and phospholipid metabolism in childhood cancers and discussed the correlation between major lipid dietary patterns (such as high-fat, ketogenic, and Mediterranean diets) and the development and progression of childhood cancers. This review also highlighted existing research gaps on the mechanisms of lipid metabolism and the effects of major lipid dietary patterns, and warranted improved research depth, experimental design, and sample size. Therefore, we advocate for future epidemiological, basic science, and multidisciplinary research in the field of childhood cancers to understand more comprehensively and profoundly the role of lipid nutrition in the prevention and treatment of pediatric cancers.